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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Actin filament organization and stability in the sarcomeres of muscle cells are critical for force generation.

Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery. In vitro , DBN-1 exhibits actin filament binding and bundling activity. In vivo , DBN-1 is expressed in body wall muscles of C. During the muscle contraction cycle, DBN-1 alternates location between myosin- and actin-rich regions of the sarcomere.

DBN-1 loss of function results in the partial depolymerization of F-actin during muscle contraction.

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Request PDF | Organic superbases, DBN and DBU, in annulation with propargylic alcohols: straightforward synthesis of Functionalized.

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We present detailed design of the DBN-based learning method including details in the offline training and Date Added to IEEE Xplore: 21 February

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