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Here we identify and functionally characterize a Caenorhabditis elegans drebrin-like protein DBN-1 as a novel constituent of the muscle contraction machinery. In vitro , DBN-1 exhibits actin filament binding and bundling activity. In vivo , DBN-1 is expressed in body wall muscles of C. During the muscle contraction cycle, DBN-1 alternates location between myosin- and actin-rich regions of the sarcomere.
DBN-1 loss of function results in the partial depolymerization of F-actin during muscle contraction.
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We present detailed design of the DBN-based learning method including details in the offline training and Date Added to IEEE Xplore: 21 February
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